Endocrine Abstracts

It is known that disoaders of the hypothalamic-pituitary-adrenal system and excess glucocorticoids in Cushing’s disease (CD) can significantly affect various organs and systems, in particular, the secretion of pituitary hormones. However, in the literature there is practically no work on the assessment of the state of tropic hormones and hormones of the peripheral glands in the early postoperative period after transsphenoidal adenomectomy. The aim of this study was to ass...

Abstract: Cushing’s disease (CD) is the heavy disease of the hypothalamic–pituitary–adrenal axis. The cause of the disease is pituitary adenoma (corticotropinoma). Hypersecretion of ACTH by a pituitary adenoma leads to increased secretion of cortisol by the adrenal cortex and the development of total endogenous hypercortisolism. The gold standard treatment for this disease is surgical removal of corticotropinoma. However, adenomectomy is not effective in all cas...

Introduction: Osteopetrosis is a rare hereditary disease caused by defective osteoclast differentiation or function. Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for some forms of osteopetrosis. HSCT is usually performed in infancy. Currently there is also experience of HSCT for osteopetrosis in adults1. In this clinical case we describe the follow-up of a patient treated with HSCT1 at the age of 28.<p class="abst...

Introduction: Long term remission of CD is achieved in 65–83% after neurosurgery, while the remaining cases have recurrence or continued tumor growth. This paper deals with the problem of CD prognostic factors after neurosurgery.Design: ACTH and cortisol blood levels, free cortisol in daily urine, MRI, histology (hemotaxiline–eosine staining) and immunohistochemistry (with antibodies to the pituitary tropic hormones, Ki-67, CD31 and VEGF) of th...

Introduction: Cushing’s disease (CD) is associated with persistent risk of cardiovascular complications, which were found to be four times higher than in age- and sex-matched population. The main cause is cardiovascular disease with thrombotic complications due to the activation of changes in haemostatic and fibrinolytic system with high level of cortisol secretion.Objective: To study hemostatic and fibrinolytic state in patients with CD.<p clas...

Introduction: Chronic endogenous hypercortisolism is characterized by abdominal obesity, systemic arterial hypertension, glucose and lipid abnormalities, insulin resistance, osteoporosis. This syndrome also has features of hypercoagulation. The mortality rate in patients with active Cushing’s disease (CD) is four times higher than in age- and sex- matched population. The main cause is cardiovascular disease with thrombotic complications.Objective: T...

In our study we included retrospective analyses of 101 patients (mean age 35 years, 85 women and 16 men) with Cushing’s disease (CD), who underwent transsphenoidal surgery (TSS) treatment. CD is based on clinical suspicion, hormonal research of cortisol (F), ACTH, 24-hous urine F, results of dexamethasone suppression tests low (1 mg) dose (LDDST) and high (8 mg) dose (HDDST) and MR-imaging (MRI). Before the operation all patients have high F, ACTH, negative LDDST and posi...

Objective: To analyze long-term treatment outcomes and to determine prognostic factors affecting the survival of patients with ECS. Matherials and methods: Retrospective, observational study on 147 patients (88 women, 59 men) with ECS diagnosed between 1990 and 2021. Various imaging studies were performed on all patients to find the source of ACTH producing neuroendocrine tumor (NET). Multivariable analysis was performed using a Cox proportional hazards ...

Cushing’s disease (CD) remission after primary surgical treatment is achieved in 70–90%, but recurrence ranges 18–25% after.The aim of this work was to study clinical, hormonal and MRI indicators before and after surgical treatment in patients with recurrent CD to identify possible predictors of recurrence. We examined 49 patients with recurrent CD in the active stage (disease duration up to 3 years). Before neurosurgery blood ACTH (median...

Phaeochromocytomas are responsible for the development ACTH-ectopic syndrome in 5% cases. Less than 1% phaeochromocytoma accompanied by symptoms of ACTH-dependent hypercortisolism. We observed four cases of ACTH-secreting phaeochromocytoma during 2 years. All patients were women from 50 to 63 years. The disease duration ranged from 6 months to 5 years. The clinical picture presented the signs of hypercortisolism (matronism, hyperpigmentation of the skin, the redistribution of ...